• Additionally we observed an increase in global O GlcNAcylati

  2019-07-06

  

  Additionally, we observed an increase in global O-GlcNAcylation levels in KRN 7000 structure tissue from mature mice, an effect more pronounced in brain cortex from WT mice (Fig. 2). In fact, it is known that age alters brain glucose metabolism [39] modulating O-GlcNAcylation levels. In accordance w

• It is well described that Tau is a

  2019-07-05

  

  It is well described that Tau is a MAP and that its phosphorylation state regulates Tau binding to MTs, which correlates with Tau aggregation and MT damage in AD [50,51]. In AD brains it was reported that Tau phosphorylation at ser396 is significantly increased when compared with other phosphorylati

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