• br Materials and methods br Results br Discussion

  2019-07-30

  

  Materials and methods Results Discussion It is intriguing that NAC improved muscle lactate levels and clinical performance probably related to its antioxidant and anti-inflammatory effect, but it was not able to improve mitochondrial function at normoxia. In general, mitochondria dysfunctio

• λ-Carrageenan It is well known that cGMP levels are reduced

  2019-07-30

  

  It is well known that cGMP levels are reduced in cerebellar slices of hyperammonemic rats; that this is due to enhanced activation of NMDA receptors and that cGMP levels are normalized by blocking NMDA receptors with MK-801 [45]. We therefore tested whether blocking NMDA receptors also normalizes cA

• The anxiety like phenotype of PDXP KO

  2019-07-24

  

  The anxiety-like phenotype of PDXP-KO mice was unexpected, given the physiological role of GABA in counteracting anxiety via GABA-A receptors [58,65,66]. However, PLP and GABA levels were already elevated postnatally in our mouse model. GABA levels affect brain development [71] and synaptogenesis [7

• The underlying mechanism of breast cancer metastasis from

  2019-07-24

  

  The underlying mechanism of breast cancer metastasis from the primary tumor to the bone is a very complex and remains to be fully elucidated [3]. The contribution of the primary tumor microenvironment to malignant progression plays a very important role [[44], [45], [46]]. Our animal model was desig

• br Materials and methods br Results br Discussion MDSCs

  2019-07-11

  

  Materials and methods Results Discussion MDSCs were originally identified as a population of cells with immunosuppressive activity in cancer [[26], [27], [28]]. Recent studies show that inflammation has a key role in inducing MDSC development and accumulation, and that MDSCs participate in

• In the early s Frank Chisari

  2019-07-08

  

  In the early 1990s, Frank Chisari's group generated transgenic mice expressing the hepatitis B virus surface antigen (HBsAg). An expression restricted to the liver was ensured by using a mouse albumin promoter. In order to break tolerance to HBsAg an adoptive transfer of activated T Thymoquinone fr

• In addition to these cell autonomous effects the gut microbi

  2019-07-08

  

  In addition to these cell-autonomous effects, the gut microbiota may be an important determinant controlling Angptl4 in a VDR-dependent manner. It is known that certain bacterial strains and specific metabolites such as short chain fatty acids can modulate Angptl4 STA-21 [46,[49], [50], [51], [52],

• Additionally we observed an increase in global O GlcNAcylati

  2019-07-06

  

  Additionally, we observed an increase in global O-GlcNAcylation levels in KRN 7000 structure tissue from mature mice, an effect more pronounced in brain cortex from WT mice (Fig. 2). In fact, it is known that age alters brain glucose metabolism [39] modulating O-GlcNAcylation levels. In accordance w

• It is well described that Tau is a

  2019-07-05

  

  It is well described that Tau is a MAP and that its phosphorylation state regulates Tau binding to MTs, which correlates with Tau aggregation and MT damage in AD [50,51]. In AD brains it was reported that Tau phosphorylation at ser396 is significantly increased when compared with other phosphorylati

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