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br Conflict of interest br The authors
2019-09-23
Conflict of interest The authors declare no conflict of interest. Acknowledgements Appendix A. Supplementary data References Contents lists available at ScienceDirect Environment International journal homepage: www.elsevier.com/locate/envint A breast cancer case-control stu
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br We compared the gene expression
2019-09-23
We compared the gene DETA NONOate detected in our cohort with data in the Human Protein Atlas [38,39] comprising mRNA-seq data of 1063 female breast cancer patients from TCGA. The 17-marker panel consists of 16 markers that have an adverse effect on survival when over-expressed. Seven of these gen
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br In this study the blood levels of OHdG as
2019-09-23
In this study, the blood levels of 8-OHdG as a biomarker of DNA damage by oxidative stress combined with the common tumor markers CEA and CA15-3 were evaluated in benign and malignant BC in comparison with their levels in normal healthy women. The levels of the studied parameters in different inva
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br After AS was performed the axillary
2019-09-23
After AS was performed, the axillary vein, long thoracic nerve and thoraco-dorsal nerve were not exposed even if a few suspicious LNs were removed, including targeted LNs and SLNs. Conventional ALND is defined as gross removal of most of the ALNs, with exposure of the axillary vein, long thoracic
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br Length Width br Sigma Aldrich St Louis
2019-09-16
Length ∗ Width2 Sigma-Aldrich, St. Louis, MO) or 2% ethanol:1× distilled phosphate buffered saline (DPBS) vehicle one week before tumor initiation. These injections continued twice a week for the remainder of the study (11 weeks in total). One week after the first 17β-estradiol or vehicle inject
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br Once ingested vitamin D the most bioavailable
2019-09-16
Once ingested, vitamin D3 – the most bioavailable form of vitamin D – is hydroxylated in the liver into 25(OH)D3, the circulating form of vitamin D3 commonly measured as ‘serum vitamin D’ [28]. 25(OH)D3 is then further hydroxylated in the kidneys to become the steroid hor-mones 1,25(OH)2D3 or 2
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br Li N Noticewala SS Williamson CW et
2019-09-16
9. Li N, Noticewala SS, Williamson CW, et al: Feasibility of atlas-based active bone marrow sparing intensity modulated Heparin therapy for cervical cancer. Radiother Oncol 123:325-330, 2017 10. Franco P, Fiandra C, Arcadipane F, et al: Incorporating (18)FDG-PET-defined pelvic active bone marr
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The prognostic role of the
2019-09-02
The prognostic role of the ratio between median AF T790M to median AF of was also investigated, confirming the results obtained by other authors, that a higher ratio is associated with deeper tumor shrinkage and better survival [21,23,24]. In fact, the ratio of T790M-to- could serve as quantificatio
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Thus we attempted to build a
2019-09-02
Thus, we attempted to build a prognostic model that combined STAS, VPI, VI and HS. Nomograms [18,19] have been validated as reliable tools to predict recurrence or survival and were used statistical prognostic models to generate the predictive probability of 5-year RFS and OS in this Calcipotriol s
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One of the major limitations of tissue
2019-08-26
One of the major limitations of tissue based biomarkers in lung cancer is that about 30% of all patients have inadequate tumor tissue for biomarker testing [45]. Blood based TMB (bTMB) is a non-invasive biomarker with the potential to independently predict clinical benefit. Blood based TMB has been
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The significant interaction effects between SES deprivation
2019-08-26
The significant interaction effects between SES deprivation and risk group make the interpretations for the main effects less meaningful, as the effect of SES deprivation differed by risk group. To directly assess and compare the SES deprivation effect by risk group, we computed the slopes of the SE
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The major strength of the study is the use
2019-08-20
The major strength of the study is the use of reliable population based data from a well validated registry program representing different parts of India which enabled a nation-wide snapshot of MM incidence profile. A possible limitation is the Conclusion Author contributions Conflict of int
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The high level of heterogeneity precluded a
2019-08-16
The high level of heterogeneity precluded a meta-analysis and means it PFK-158 is difficult to draw any firm conclusions about the diagnostic potential of these biomarkers for detecting recurrence. We therefore summarise the findings of the eligible studies narratively. Numerical results regarding d
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Introduction In recent years the mortality
2019-08-16
Introduction In recent years, the mortality rate of all cancer has decreased significantly, save for one. Pancreatic cancer remains elusive to treatment, and is the fourth leading cause of cancer-related death in the world [1]. First described in 1761 by Giovanni Battista Morgagni, an Italian patho
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Limitations of this study were the absence of
2019-08-16
Limitations of this study were the absence of follow-up colonoscopy for negative FIT results ( age for their screening programmes [6]. Considering the recommendation of the EU to include the age range of 50–55, this would most likely increase the ratio between normal and pathological findings after