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br Cytosolic lactate dehydrogenase LDH is
2022-05-22
Cytosolic lactate dehydrogenase (LDH) is used as a marker of cell death for in vitro models since LDH is released through the compro-mised cell membrane. The finding that MDA-MB-231 cells treated with BthTX-II display a decreased LDH activity, may justify the presence of necrotic or late apoptotic
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Journal of Ethnopharmacology br reaction
2022-05-22
Journal of Ethnopharmacology 236 (2019) 100–107 reaction of the fluorescent cell viability dye. Living GW9662 reduce blue resazurin into the pink colored and highly red fluorescent resorufin (Präbst et al., 2000). 2. Material and methods 2.1.1. Aqueous mistletoe preparations Iscucin®
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br T W Costantini X Dang R Coimbra B
2022-05-22
[17] T.W. Costantini, X. Dang, R. Coimbra, B.P. Eliceiri, A. Baird, CHRFAM7A, a human-specific and partially duplicated alpha7-nicotinic MK-571 receptor gene with the potential to specify a human-specific inflammatory response to injury, J. [18] A.M. de Lucas-Cerrillo, M.C. Maldifassi, F. Arnal
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br The nanomedicine has got rapid development
2022-05-20
The nanomedicine has got rapid development and wide concern in recent years. Various nanomaterials with different sizes, physico-chemical properties and surface morphologies were utilized to design proper delivery systems for compounds, antibodies, siRNAs and other agents in the treatment of cancer
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br Fig e Orthotopic LS T
2022-05-20
Fig. 5 e Orthotopic LS174T tumor. (A) Bright-light imaging demonstrates visible local metastases. (B) Fluorescence imaging shows identifiable margins of the tumor and nearby metastases. (Color version of figure is available online.) antibody is conjugated to the NIR dye, the antibody binds to
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Navitoclax br Our results demonstrated that
2022-05-19
Our results demonstrated that ADT induces ZBTB46 expression through the downregulation of the androgen-responsive SAM pointed domain containing ETS transcription factor (SPDEF), leading to in-creased expression of PTGS1 and contributing to NE differentiation of prostate cancer cells. The addition o
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br Cell viability assay br Cell viability
2022-05-17
2.2. Cell viability assay Cell viability was determined by quantitation of ATP, an indicator of live cells, using the CellTiter-Glo luminescent cell viability assay kit (Promega, Madison, WI, USA), as described previously [19,32]. Briefly, SB 203580 (4000 cells/well) were grown in 96-well plat
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br to inform bioinformatics variant detection and interpretation enables the
2022-05-17
to inform bioinformatics variant detection and interpretation enables the suppression of false-positive variant calls and flags samples at risk of false-negative calls, thus enabling accurate analysis of poorer-quality specimens. The analytical validity of our approach is supported by 100% con
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br Compared with the traditional ELISA test that
2022-05-15
Compared with the traditional ELISA test that is based on the principle of an enzyme-linked immunoassay, the nanomaterial-based biosensing assay has high sensitivity and good accuracy and offers many advantages such as elimination of labeled antibody and no need for sophisticated equipment and hig
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br Image segmentation br Image segmentation is an operation
2022-05-15
2.2. Image segmentation Image segmentation is an operation that separates an image into non-overlapping fragments. The Otsu’s global thresholding is one of the most straightforward and practical approaches to segment an image into foreground and background objects [31]. In this type of segme
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br Next we examined whether
2022-05-13
Next, we examined whether AMPK affects NANOG stability dependent on the presence of SPOP. Our data indicated that in-hibition of AMPK by compound C prolonged the half-life of NANOG in SPOP+/+, but not SPOP / DU145 6-Hydroxydopamine (Figures 5C and 5D). Consistently, AMPK affected the ubiquitin
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br downstream from AKT br AKT is known to
2022-05-10
downstream from AKT2. AKT is known to phosphorylate proteins on the consensus sequence RXRXX (S/T). Using the bioinformatics method described by Vandermoere et al. [24] to search for the AKT phosphorylation site in HK2, we found that HK2 contains the typical AKT phosphorylation sequence, QHR
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br For the patients with non endometrioid tumors
2022-05-09
For the 91 patients with non-endometrioid tumors, the 5-year rates of pelvic disease control (87% vs. 59%, P = 0.01), DSS (65% vs. 38%, P = 0.02), and OS (63% vs. 35%, P = 0.01) were all significantly higher for those who received RT ± CT than for those who received adjuvant CT alone (DSS, Fig. 3)
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br In conclusion our results suggest that both
2022-05-09
In conclusion, our results suggest that STA-4783 both a history of diabetes and adiposity (overall and central) are associated with increased risk of pancreatic cancer. Acknowledgments This work was supported by institutional funds from the Albert Einstein College of Medicine. The WHI progr
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More than ubiquitination sites in mammalian cells are deubiquitinated by
2022-05-09
More than 20,000 ubiquitination sites in mammalian ML385 are deubiquitinated by a pool of ∼100 DUBs (Leznicki and Kulathu, 2017, Mevissen and Komander, 2017). We find the BRCC36-containing BRCA1-A and BRISC complexes to be modular DUBs, with ABRAXAS and ABRO1 specifically integrating accessory fact