• br thermal stability of a peptide As

  2022-08-11

  

  thermal stability of a peptide. As shown in supplementary Table1, bu-forin II and buforin IIb are cationic peptides with good thermal stabi-lity. Buforin IIb has more positive charges and the thermal stability of buforin IIb is also stronger than that of buforin II. From the data of GRAVY and hydr

• br Neoadjuvant therapy will be continuously g http

  2022-08-11

  

  Neoadjuvant therapy will be continuously guided by image-based functional biomarkers There are advantages with neoadjuvant therapy: the algo-rithmic choice of therapy can be evaluated in terms how it affects the actual tumor, and increase post-surgical compliance with adjuvant treatment. The tu

• br Methods br This was a secondary analysis

  2022-07-28

  

  Methods This was a secondary analysis of a large, national, multicenter study of BTcP that Calcitriol involved 32 centers [21]. The local ethical committees approved the protocol at each center, and written informed consent was obtained from each patient. Patients were seen as outpatient, inpa

• br Unukovych D Sandelin K

  2022-07-26

  

   [8] Unukovych D, Sandelin K, Liljegren A, Arver B, Wickman M, Johansson H, et al. Contralateral prophylactic mastectomy in breast cancer patients with Laurdan family history: a prospective 2-years follow-up study of health related quality of life, sexuality and body image. Eur J Cancer 2012;48:

• br Our primary outcomes include prostate cancer low grade

  2022-07-26

  

  Our primary outcomes include prostate cancer, low-grade prostate cancer (Gleason 6), and high-grade prostate cancer (Gleason 7–10). The analytic approach in modeling was conceptually a stratified analysis by race, with a combined analysis for the investigation of race interactions. Primary analyse

• BMS-936558 br legend continued on next page br Molecular

  2022-07-25

  

  (legend continued on next page) Molecular Therapy engineered as oncolytic agents for therapeutics against different can-cer types, including PDAC.17,18 Upon adenoviral infection, cellular miRNA profiles suffer profound changes that influence viral replica-tion.10,11,19 For this reason, dy

• br Introduction br Advances in biological therapies

  2022-07-25

  

  1. Introduction Advances in biological therapies such as anti-epidermal growth factor receptor (EGFR) EGCG (cetuximab and panitumumab) have resulted in biomarkers being used to target metastatic CRC (mCRC) [11]. KRAS is a key proto-oncogene downstream of EGFR and is activated in up to 50% of s

• br DLS studies were conducted to

  2022-07-25

  

  DLS studies were conducted to obtain the mean particle size and surface charge of the Coleus aromaticus extract-mediated CuO NPs. Fig. 4A shows the size distribution of the CuO NPs; a mean particle size of 33 nm was observed, and the size distribution was in agreement with the TEM results. The sur

• br in Caki cells following incubation with

  2022-07-25

  

  in Caki-1 cells, following incubation with bimetallic TieAu Tita-nocref (2), Titanofin (4) and monometallic Au cref (2), fin (3) and Auranofin as a positive control (Fig. 5). After 72 h of incubation Caki-1 TrxR activity is significantly reduced by Auranofin (86%), after 24 h of incubation there w

• br expression levels of Bax and cleaved caspase in

  2022-07-25

  

   expression levels of Bax and cleaved caspase‐3 in HCT116 cells. Col-lectively, these results suggested that BA triggers colorectal cancer MK-571 apoptosis. 2.3. BA induces apoptosis through mitochondria-mediated apoptotic pathway inhuman colorectal cells On the basis of the observed chan

• br Fig Antitumor e ects of administration

  2022-07-06

  

  Fig. 5. Antitumor effects of administration of BCG-induced NETs. A & B, comparison of differently treated subcutaneous tumors showed that the weights were significantly reduced in NETs and DNase-pretreated NETs group, but non-significantly in the boiling-inactivation group (* denote comparision t

• br Normal fibroblast cells neighboring tumor

  2022-07-06

  

  Normal fibroblast cells neighboring tumor cells acquire a phenotype known as the cancer-associated fibroblasts (CAFs), where autophagic activity supported the high demand of cancer cells for the energy and nutrient support (Martinez-Outschoorn et al., 2011). Injection of CAFs overexpressing pro-au

• Finally we investigated whether serum CRP levels

  2022-06-21

  

   Finally, we investigated whether serum CRP levels were associated with incidents of cancer using multivariable Cox regression analysis and the results are summarized in Table 4. Among the 2753 study partici-pants, a total of 177 cases were identified during the follow-up as having experienced can

• br Consistent with how the TP

  2022-06-21

  

  Consistent with how the TP53 mutational landscape in lung cancer  is described in the literature, 56.9% of the patients in our cohort har-bored TP53 mutations, 73.2% of which were missense mutations [16]. As previously reported, 34.1% of reported mutations in our cohort were G-to-T transversi

• br Table e Patient and tumor characteristics br Smoker never

  2022-05-30

  

  Table 1 e Patient and tumor characteristics. Smoker/never smoker/unknown 300/98/2 Pack-years, average (range) 44 (0e225) ECOG Performance Status Adenocarcinoma 228 Squamous cell carcinoma 61 Non-small cell carcinoma, NOS 28 Others 14 Small cell carcinoma 69 Driver gene mutation

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