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Introduction In recent years the mortality
2019-08-16
Introduction In recent years, the mortality rate of all cancer has decreased significantly, save for one. Pancreatic cancer remains elusive to treatment, and is the fourth leading cause of cancer-related death in the world [1]. First described in 1761 by Giovanni Battista Morgagni, an Italian patho
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Limitations of this study were the absence of
2019-08-16
Limitations of this study were the absence of follow-up colonoscopy for negative FIT results ( age for their screening programmes [6]. Considering the recommendation of the EU to include the age range of 50–55, this would most likely increase the ratio between normal and pathological findings after
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Germ cell tumors are the most common histologic subtype
2019-08-16
Germ cell tumors are the most common histologic subtype of testicular cancer in all age groups [37] and the majority of etiologic studies of testicular cancer have focused on GCT. In the AYA group, 98% of testicular cancers arise in the germ cells, so the results of TGCT studies would apply to the v
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br Conclusion Prevalence is useful for quantifying the numbe
2019-08-11
Conclusion Prevalence is useful for quantifying the number of people with potentially specific medical needs or social difficulties. In France, as in most other developed countries where incidence and survival are high, prevalent cases are numerous, representing around 5% of the AMG 925 and up t
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In the International Collaboration of
2019-08-11
In 2007, the International Collaboration of Epidemiological Studies of Cervical Cancer combined individual participants’ data from 25 studies involving 16,573 women with invasive cervical cancer, in situ cervical cancer or CIN 3 (cases) and 35,509 women without cervical disease (controls) [11]. The
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The overall survival rate of thyroid
2019-08-11
The overall survival rate of thyroid cancer has improved in parallel with the increasing incidence [2]. The introduction of iodine therapy is among the improved treatment modalities for differentiated thyroid cancer [7]. In Denmark, thyroid cancer is treated at highly specialized university centers
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Introduction Ovarian cancer is the leading cause
2019-08-11
Introduction Ovarian cancer is the leading cause of death among gynecologic malignancies, chiefly due to the large proportion of cases diagnosed at advanced stage [[1], [2], [3]]. Optimal debulking (Conessine is unclear whether NACT provides a survival benefit. In the U.S., the role of NACT in adv
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3X FLAG Peptide The prevalence described in the meta
2019-08-11
The prevalence described in the meta-analysis and the 95% confidence intervals (CI95%) were estimated by the random effects model, weighted by the size of the study. Heterogeneity across studies was analyzed by the fixed effect model of the inverse variance, and the magnitude of inconsistency was es
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br Materials and methods br Results br Discussion
2019-07-30
Materials and methods Results Discussion It is intriguing that NAC improved muscle lactate levels and clinical performance probably related to its antioxidant and anti-inflammatory effect, but it was not able to improve mitochondrial function at normoxia. In general, mitochondria dysfunctio
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λ-Carrageenan It is well known that cGMP levels are reduced
2019-07-30
It is well known that cGMP levels are reduced in cerebellar slices of hyperammonemic rats; that this is due to enhanced activation of NMDA receptors and that cGMP levels are normalized by blocking NMDA receptors with MK-801 [45]. We therefore tested whether blocking NMDA receptors also normalizes cA
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The anxiety like phenotype of PDXP KO
2019-07-24
The anxiety-like phenotype of PDXP-KO mice was unexpected, given the physiological role of GABA in counteracting anxiety via GABA-A receptors [58,65,66]. However, PLP and GABA levels were already elevated postnatally in our mouse model. GABA levels affect brain development [71] and synaptogenesis [7
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The underlying mechanism of breast cancer metastasis from
2019-07-24
The underlying mechanism of breast cancer metastasis from the primary tumor to the bone is a very complex and remains to be fully elucidated [3]. The contribution of the primary tumor microenvironment to malignant progression plays a very important role [[44], [45], [46]]. Our animal model was desig
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br Materials and methods br Results br Discussion MDSCs
2019-07-11
Materials and methods Results Discussion MDSCs were originally identified as a population of cells with immunosuppressive activity in cancer [[26], [27], [28]]. Recent studies show that inflammation has a key role in inducing MDSC development and accumulation, and that MDSCs participate in
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In the early s Frank Chisari
2019-07-08
In the early 1990s, Frank Chisari's group generated transgenic mice expressing the hepatitis B virus surface antigen (HBsAg). An expression restricted to the liver was ensured by using a mouse albumin promoter. In order to break tolerance to HBsAg an adoptive transfer of activated T Thymoquinone fr
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In addition to these cell autonomous effects the gut microbi
2019-07-08
In addition to these cell-autonomous effects, the gut microbiota may be an important determinant controlling Angptl4 in a VDR-dependent manner. It is known that certain bacterial strains and specific metabolites such as short chain fatty acids can modulate Angptl4 STA-21 [46,[49], [50], [51], [52],
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